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Parkinson’s disease is a long term degenerative disorder of the central nervous system that mainly affects the motor system. Dopamine agonists are used in the treatment of parkinson’s disease. Ropinirole is a dopamine agonist used in the treatment of parkinson’s disease. Creatinine is a chemical waste molecule i.e. generated from muscle metabolism. Abnormally high levels of creatinine may indicate kidney damage or CKD. Few studies have been reported that the creatinine levels in parkinson’s patients increase with ropinirole administration. This review is designed to investigate the rise in creatinine levels while taking ropinirole as an anti- parkinson’s drug. The study is planned to conduct at Pushpagiri Medical College Hospital under the Neurology Department.